Nrf2 activation is a research area focused on understanding the role of nuclear factor erythroid 2-related factor 2 (Nrf2) in cellular defense mechanisms. Nrf2 is a transcription factor that plays a crucial role in regulating the expression of genes involved in antioxidant and detoxification pathways. Activation of Nrf2 can enhance the cellular response to oxidative stress and protect against various diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. Researchers are investigating various strategies to activate Nrf2 pharmacologically or through lifestyle interventions to harness its protective effects and develop potential therapeutics for combating oxidative stress-related disorders.